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pentobarbital will reduce the level or impact of parecoxib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Not known.pentobarbital decreases effects of sufentanil SL by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of CYP3A4 inducers may well reduce sufentanil degre